Volumen 16 número 3 - Octubre 2019
ISSN 0718-0918
Tabla de Contenidos > Puesta al Día
Yadira Janet González Paredes
Médico Hematólogo Pediatra
Servicio de Pediatría ISSSTE
Veracruz, México

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Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal and acquired disease caused by a somatic mutation in the PIG-A gene found on the X chromosome and encoding a protein involved in the synthesis of glycosylphosphatidylinositol (GPI), which serves as anchoring to many proteins of the cell membrane producing greater sensitivity to complement. The different signs and symptoms that appear have a great impact on the quality of life of patients, so a correct diagnosis is of vital importance. Currently, multiparameter flow cytometry is the methodology of choice to detect and follow the patient with PNH.

Key words: Paroxysmal nocturnal hemoglobinuria
Revista Pediatría Electrónica
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ISSN 0718-0918