LINFOMA NO HODGKIN: PRIMERA Y SEGUNDA NEOPLASIA O, TRANSFORMACIÓN HISTOLÓGICA. DIFICULTAD DIAGNÓSTICA. REPORTE DE UN CASO
Yadira Janet González Paredes¹, Sandra Flor Páez Aguirre¹, Farina Esther Arreguín González¹, Blanca Olivia Almazán García¹, Lourdes Amanecer Bustamante Lambarén¹, Karen Xiomara Álvarez Toledo¹, San Juanita Sandoval de Jesús¹, Violeta Ordoñez Espinosa².
¹ Oncología Pediátrica, Centro Médico Nacional “20 de noviembre” ISSSTE, México
² Anatomía Patológica, Centro Médico Nacional “20 de noviembre” ISSSTE, México

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FL is a heterogeneous disease with many different subgroups, in terms of age of onset, organs involved (especially extranodal sites) and genetic abnormalities. With great variations in the clinical course, sometimes very indolent or not; can show transformation to high-grade lymphomas, transformations to Diffuse Large B Cell Lymphoma (this being the most common), Burkitt's, Leukemia / Lymphoma, Lymphoblastic

Lymphoma (reported rarely), with an aggressive clinical course have been reported. In 2008 the WHO established 3 new variants: 1) Pediatric FL, 2) Intestinal Primary FL and 3) in situ FL. Pathologists and clinicians must consider these pathologies when deciding on diagnosis and treatment. Histological transformation refers to the biological event that leads to the development of high-grade aggressive Non-Hodgkin's Lymphoma in patients with an underlying FL.  Pediatric Follicular Lymphoma (FL) is an excessively rare neoplasm, which differs from adult FL.

Key Follicular Lymphoma