DIABETES DE INICIO PRECOZ EN PACIENTES CON FIBROSIS QUÍSTICA, A PROPÓSITO DE 3 CASOS
Valentina Basualto R.1, Magdalena Mira O.2,3, Rodrigo Bozzo H.2, M. Genoveva
Parra O.2, Paulina Balboa C2,3, María José́ Pinochet2, María Angélica Palomino2,3
1 Becada de Pediatría. Universidad de Chile.
2 Departamento de Pediatría y Cirugía Infantil, Campus Norte, Universidad de Chile.
3 Equipo de Fibrosis Quística, Hospital Roberto del Río.
Resumen |Abstract | Texto completo | Descargar cuerpo en pdf |
Introduction: Diabetes is the most common extra pulmonary complication in adults with cystic fibrosis (CF). There are few reports of diabetes related to (CF) in preschool children worldwide. Prevalence in Chile is unknown.
Método: We report ta serie of three cases of children with CF and diagnosis of diabetes at an early age. Case 1: Boy 8 year old, CF diagnosed at the age of 3 months by sweat test and genetic study p.Phe508del/-. He presented non-ketotic hyperglycemia since he was 6 months old, with tracheal colonization of Staphylococcus Aureus (SA) and Pseudomona Aeruginosa (PA) , and diagnosis of diabetes at the age of 2 years 1 month. Case 2: Boy patient, 16 years old, with diagnosis of CF at the of age 7 months by sweat test and genetic study p.Phe508del/-. He presents tracheal colonization by SA and multiple PA infections. At the age 5 years 7 months, diabetes is diagnosed, presenting ketosis at the beginning. Case 3: Boy 13 years diagnosed with CF at the age of 7 months, presented sweat test and genetic study p.Phe508del/-. He presents tracheal colonization by SA and multiple infections.
Discussion: CF related diabetes is common in adults with cystic fibrosis, but it can be diagnosed in early childhood. A high level of suspicious is required for a proper and timely diagnosis
Key words: Cystic fibrosis, cystic fibrosis-related diabetes, prevalence, morbidity and mortality, preschool children. |
