Objective: The aim of this study is to develop a protocol for the diagnosis and management of Kawasaki disease, based on the available scientific evidence.

Methodology: A systematic review was carried out to locate, synthesise and analyse the available scientific evidence. The databases searched were: MEDLINE (via OVID), EMBASE, Web of Science (WOS), Epistemonikos database, Cochrane Library and specific web pages of clinical practice guidelines, with the terms "'mucocutaneous lymph node syndrome", "Kawasaki disease" and "Kawasaki syndrome". A telematic questionnaire was also administered to patients and relatives. A series of recommendations were drawn up based on the information collected and the main issues raised by patients. 168 recommendations were voted on using Delphi methodology by a panel of multidisciplinary experts involved in the care of patients with this pathology.

Results: A total of 165 recommendations for diagnosis, treatment and follow-up were obtained, with the consensus of the panel of experts. These recommendations were set out in a care protocol, and graphically in 2 algorithms to make it easier for healthcare personnel to understand and apply the selected recommendations.

Conclusions: Kawasaki disease remains a poorly understood disease, but controllable with diagnosis, early treatment and appropriate follow-up. For this reason, it is essential to unify criteria in the management of these patients. Clinical protocols are a valuable tool that provides information to professionals and helps in decision-making.

Keywords: Kawasaki disease, mucocutaneous lymph node syndrome, coronary aneurysm, vasculitis, systematic review, patient participation, delphi technique, surveys and questionnaires, algorithms, clinical protocol.